-
GLP-1 (9-36) amide Assay Workflow
2026-09-04
Use GLP-1 (9-36) amide as a practical receptor-attribution tool for separating direct GLP-1R activity from glucagon-driven cAMP signals. This guide combines peptide handling, FRET assay design, comparative controls, and troubleshooting for GLP-1 receptor signaling research and metabolic studies.
-
Anti-HMGB1 Rabbit Monoclonal Antibody Guide
2026-09-03
The Anti-HMGB1 Rabbit Monoclonal Antibody MA3057 is designed for research detection of HMGB1 in human, mouse, and rat samples by Western blot, immunohistochemistry, and flow cytometry. It should be used as an unconjugated research reagent, not as a diagnostic, therapeutic, or medical-use product, and no directly matched paper evidence is supplied for this specific SKU.
-
Regorafenib (BAY 73-4506) in Cancer Research
2026-09-03
Regorafenib, also called BAY 73-4506, is an orally active multikinase inhibitor used in angiogenesis research, tumor biology, and oncology workflows. Product data and a peer-reviewed melanoma study link its activity to broad kinase inhibition, reduced tumor progression, RRM2 downregulation, and ERK/E2F3 pathway suppression.
-
Candida krusei and Apoptosis in Mammary Epithelial Cells
2026-09-02
Miao and colleagues show that the yeast and hypha phases of Candida krusei trigger bovine mammary epithelial-cell apoptosis through different dominant signaling routes. The study connects fungal morphology with mitochondrial or death ligand/receptor mechanisms and identifies TLR2/ERK and JNK/ERK signaling as shared regulatory axes relevant to mastitis research.
-
Berberine, SIRT6-AMPK, and AF Fibrosis
2026-09-02
The reference study identifies SIRT6-AMPK signaling as a mechanistic link between angiotensin II stress, NLRP3 inflammasome activation, atrial fibrosis, and susceptibility to atrial fibrillation. Using human atrial samples, bioinformatics, an angiotensin II-induced mouse model, and SIRT6 gain- and loss-of-function experiments, the work shows that berberine protects atrial structure and electrical stability through this pathway.
-
Intravesical p21 mRNA–LNP Therapy in Bladder Cancer
2026-09-01
The reference study develops lipid nanoparticles carrying chemically modified CDKN1A/p21 mRNA for localized intravesical tumor suppressor replacement. Its cell, tissue, reporter-distribution, and orthotopic mouse experiments connect transient p21 restoration with cell-cycle inhibition, DNA-damage accumulation, apoptosis, and reduced bladder tumor growth.
-
GDC-0941: Reframing PI3K Resistance Biology
2026-08-31
A mechanistic and translational framework for using GDC-0941 to interrogate PI3K/Akt-driven therapy resistance, cancer stem cell phenotypes, and biomarker-guided oncology strategies.
-
CpAdhE Inhibition in Cryptosporidium parvum
2026-08-31
The reference study identifies the bacterial-type bifunctional aldehyde/alcohol dehydrogenase CpAdhE as a tractable metabolic target in Cryptosporidium parvum and finds lower-micromolar inhibition by several antifungal imidazoles. Its enzyme-to-cell validation workflow provides a useful framework for prioritizing antiparasitic chemical matter while highlighting the need for selectivity and in vivo studies.
-
GSK3 Inhibition as Host-Directed TB Therapy
2026-08-30
The 2024 iScience study identified glycogen synthase kinase 3 (GSK3) as a host pathway that supports intracellular Mycobacterium tuberculosis growth. Its combination of chemical screening, CRISPR and RNAi validation, macrophage apoptosis analysis, and phosphoproteomics provides a rationale for host-directed tuberculosis therapy rather than relying only on direct-acting antimicrobials.
-
Ionomycin Free Acid: Calcium Ionophore Guide
2026-08-29
Ionomycin free acid is a calcium ionophore research reagent that raises intracellular calcium by facilitating Ca2+ movement across lipid membranes. Its documented oocyte-activation activity supports developmental assays, while its use as a perturbation tool in FAISL–FAK cancer signaling remains a testable research hypothesis.
-
Streptavidin-Cy3 Workflows for Biohybrid Microrobot Assays
2026-08-29
Learn how to use Streptavidin-Cy3 to visualize biotinylated probes, surface markers, and localization patterns in barrier-penetrating biohybrid microrobot studies. The workflow combines practical fluorescence controls with assay choices inspired by magnetically guided Euglena-based tumor-targeting research.
-
GW 4869 (hydrochloride hydrate): Lab Guide
2026-08-28
This scenario-based guide explains how GW 4869 (hydrochloride hydrate), SKU C4769, can improve the interpretation of viability, cytotoxicity, and extracellular-vesicle experiments. It covers mechanism, controls, formulation, protocol optimization, data interpretation, and practical supplier selection.
-
Xyleborus affinis Fungal Symbionts and Mycangia
2026-08-28
The reference study improves characterization of ambrosia beetle–fungus mutualisms by showing that ethanol washing can reduce recovery of mycangial fungi and by experimentally testing isolate colonization. Its results expand the known fungal consortium of Xyleborus affinis while providing a practical framework for distinguishing viable symbionts from incidental associates.
-
Red Blood Cell Lysis Buffer in Osteogenic Translation
2026-08-27
Translational osteogenic research increasingly depends on connecting cell-intrinsic mechanisms with reliable blood-based measurements. This article examines how selective erythrocyte removal can strengthen that bridge while placing the RUNX2–AMPK findings from trelagliptin research in their proper experimental and translational context.
-
SAR405: A Precision Vps34 Inhibitor Workflow
2026-08-27
SAR405 enables direct, selective interrogation of Vps34-dependent PI3P production alongside upstream AMPK–ULK1 signaling. This workflow combines dose-controlled autophagy inhibition, vesicle trafficking modulation, and lysosome function impairment with practical controls for starvation and mTOR-inhibitor experiments.
455 records 6/31 page Previous Next First page 上5页 678910 下5页 Last page